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招聘公众号
抗体Fc片段与新生儿Fc受体（FcRn）的亲和力是决定抗体半衰期的关键因素。FcRn通过受体介导的再循环机制有效保护IgG避免在溶酶体中降解，从而延长IgG的半衰期。为支持抗体药物和自身免疫性疾病靶向FcRn药物开发，我们可为您提供一系列高质量FcRn产品。
| 分子 | 货号 | 产品描述 | 订购/预购 |
|---|---|---|---|
| FcRn (FCGRT & B2M) | FCM-C5284 | Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & MALS verified) | |
| FCM-C52W8 | Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified) | ||
| FCM-C52W9 | Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified) | ||
| FCM-C82W3 | Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified) | ||
| FCM-C82W5 | Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Strep II Tag (HPLC&SPR&BLI verified) | ||
| FCM-C82W9 | Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified) | ||
| FCM-H5283 | Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified) | ||
| FCM-H5286 | Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & HPLC-verified) | ||
| FCM-H8286 | Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, ultra sensitivity (primary amine labeling) (HPLC & SPR verified) | ||
| FCM-H82W4 | Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (SPR & BLI & HPLC verified) | ||
| FCM-H82W7 | Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified) | ||
| FCM-M52W2 | Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Twin-Strep Tag (MALS & BLI verified) | ||
| FCM-M52W8 | Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified) | ||
| FCM-M82W5 | Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & BLI verified) | ||
| FCM-M82W6 | Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Twin-Strep Tag (MALS & BLI-verified) | ||
| FCM-P5280 | Porcine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified) | ||
| FCM-R5287 | Rat FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified) | ||
| FCM-R52W5 | Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified) | ||
| FCM-R82W6 | Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified) | ||
| FCM-R82W7 | Biotinylated Rat FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (MALS & SPR verified) | ||
| FCN-B82W3 | Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified) | ||
| FCN-F82W3 | Biotinylated Feline FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified) | ||
| FCN-H52W7 | Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & BLI & MALS verified) |
The purity of Canine FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (Cat. No. FCM-C52W8) is more than 90% and the molecular weight of this protein is around 43-60 kDa verified by SEC-MALS.
Immobilized Biotinylated Human FCGRT&B2M Heterodimer Protein, His,Avitag (Cat. No. FCM-H82W7) on SA Chip can bind Herceptin® with an affinity constant of 0.267 μM as determined in a SPR assay (Biacore 8K) (QC tested).
申请 Protocol
Loaded Cynomolgus / Rhesus macaque FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (Cat. No. FCM-C5284 ) on SA Biosensor via Biotin his antibody, can bind Herceptin with an affinity constant of 0.13 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
申请 Protocol治疗性抗体的功效不仅取决于其Fab片段结合靶抗原的活性，还取决于其Fc片段与Fc受体的相互作用。Fc片段和FcγRⅢA（CD16a）的结合会影响抗体依赖的细胞介导的细胞毒性作用（ADCC）。优化抗体结构，筛选获得和Fc受体亲和力最理想的抗体，是发展治疗性抗体药物的一个重要途径。我们基于丰富的蛋白产品资源和活性分析经验提供一系列Fc受体蛋白产品助力抗体药物功能验证！
The purity of Human CD32a (R167), His Tag (Cat. No. CDA-H5221) is more than 90% and the molecular weight of this protein is around 25-35 kDa verified by SEC-MALS.
Human CD64, His Tag (Cat. No. FCA-H52H1) captured on CM5 chip via anti-His antibody can bind Herceptin® with an affinity constant of 4.92 nM as determined in a SPR assay (Biacore 8K) (QC tested).
申请 Protocol
Loaded Human CD16a (V176), His Tag (Cat. No. CD8-H52H4) on HIS1K Biosensor, can bind Herceptin with an affinity constant of 0.447 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
申请 Protocol
SPR验证，固定在CM5芯片上的Human Fc gamma RIIB / CD32b Protein (Cat. No. CDB-H5228)可以结合Rituximab (利妥昔单抗)，亲和常数为10μM (Biacore T200)。
为助力治疗性抗体体外功能验证，我们推出ADCC / ADCP功能验证报告基因细胞株。通过基因工程改造，在Jurkat细胞内转入一个受NFAT信号调控驱动的Luciferase报告基因，同时使其在细胞膜表面表达一种FcγR。当将该细胞与靶细胞和相关抗体共培养时，抗体同时结合靶细胞抗原和该细胞表面Fcγ受体，导致受体聚集、细胞内信号传导和NFAT介导的Luciferase 报告基因表达与发光。
| 分子 | 货号 | 产品描述 | 订购/预购 |
|---|---|---|---|
| Fc gamma RIIIA / CD16a | SCJUR-STF067 | Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service | |
| SCJUR-STF068 | Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service | ||
| Fc gamma RIIA / CD32a | SCJUR-STF069 | Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service | |
| SCJUR-STF070 | Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service | ||
| Fc gamma RIIB / CD32b | SCJUR-STF071 | Human CD32b (Luc) Jurkat Reporter Cell Development Service | |
| Fc gamma RI / CD64 | SCJUR-STF072 | Human CD64 (Luc) Jurkat Reporter Cell Development Service |
Human CD64, His Tag (Cat. No. FCA-H52H1) captured on CM5 chip via anti-His antibody can bind Herceptin® with an affinity constant of 4.92 nM as determined in a SPR assay (Biacore 8K) (QC tested).
申请 Protocol
Loaded Human CD16a (V176), His Tag (Cat. No. CD8-H52H4) on HIS1K Biosensor, can bind Herceptin with an affinity constant of 0.447 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
申请 Protocol
SPR验证，固定在CM5芯片上的Human Fc gamma RIIB / CD32b Protein (Cat. No. CDB-H5228)可以结合Rituximab (利妥昔单抗)，亲和常数为10μM (Biacore T200)。
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