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AGLink® ADC Conjugation Kit (Tetrazine, DAR2&4, 1mg)

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货号-规格
价格
Qty.
ADC-P006-1Reaction
¥9450.00
合计0件 产品金额¥ 0

产品详情

  • 组分(Materials Provided)

    BoxA(-20°C)
    ID
    Components
    Size
    ADC-P006-C01
    20 x Reaction buffer
    55ul
    ADC-P006-C02
    Cofactor A
    55ul
    ADC-P006-C03
    Cofactor B
    55ul
    ADC-P006-C04
    Substrate A
    30ul
    ADC-P006-C05
    Substrate B
    30ul
    ADC-P006-C06
    Enzyme A
    30ul
    ADC-P006-C07
    Enzyme B
    30ul
    ADC-P006-C08
    Enzyme C
    25ul
    BoxB(4°C)
    ID
    Components
    Size
    ADC-P006-1-C01
    Binding buffer
    15ml
    ADC-P006-1-C02
    Elution buffer
    1.5ml
    ADC-P006-1-C03
    Neutralization buffer
    0.5ml
    ADC-P006-1-C04
    250 mM Tris-HCl buffer (pH7.5)
    1.5ml
    ADC-P006-1-C05
    10×PBS (pH7.2- 7.4)
    6ml
    ADC-P006-1-C06
    Desalting column
    2per
    ADC-P006-1-C07
    Concentrator tube
    2per
    ADC-P006-1-C08
    ProteinA Resin
    100ul*2
  • 产品概述(Product Overview)

    Antibody-drug conjugates (ADC) is a type of fast growing anticancer drug. Monoclonal antibody is conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. AGLink® ADC conjugation kit is designed to conjugate mAb with Tetrazine though site-specific enzymatic reaction.

  • 应用说明(Application)

    AGLink® ADC Conjugation Kit (Tetrazine, DAR2&4, 1mg) is designed to conjugate 1mg mAb with Tetrazine through site-specific enzymatic reaction.

    It is for research use only.

  • 存储(Storage)

    BoxA: The unopened kit is stable for 18 months from the date of manufacture if stored under temperature ≤ -20°C. The opened kit should be stored according to components table.

    BoxB: The unopened kit is stable for 18 months from the date of manufacture if stored under 4°C. The opened kit should be stored according to components table.

  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 典型数据-Typical Data

    Please refer to DS document for the assay protocol.

     Tetrazine TYPICAL DATA

    ADC DAR value assessment by LC-TOF/MS

  •  Tetrazine TYPICAL DATA

    1.Analyst TF 1.8.1 Software was used to collect LC-TOF/MS data of samples in positive ion mode
    2.PeakView was used for data processing and BioToolKit was used for deconvolution analysis.
    3.DAR values are calculated using the following formula:
    DAR4 =(226.11*4+114.21*3+26.32*2+14.53*1)/(226.11+114.21+26.32+14.53)=3.45

  •  Tetrazine TYPICAL DATA

    ADC DAR value assessment by LC-TOF/MS

  •  Tetrazine TYPICAL DATA

    1.Analyst TF 1.8.1 Software was used to collect LC-TOF/MS data of samples in positive ion mode
    2.PeakView was used for data processing and BioToolKit was used for deconvolution analysis.
    3.DAR values are calculated using the following formula:
    DAR2 =(1041.76*4+116.65*2)/(1041.76+116.65)=1.90

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重要声明

  • Statement of Rights

    AGLink products are co-developed by ACROBiosystems Co., Ltd. and Glyco-therapy Biotechnology Co., Ltd. based on Glyco-therapy's conjugation platform (YTConju?) and are not authorized for commercial use. The sale and use of AGLink products doesn't represent any forms of license or authorization of the attached technologies for developing any diagnostic, therapeutic or prophylactic products for commercial purposes.

  • Note of application

    AGLink products are intended for research use only by the Buyer or its users and can not be used for any other purposes, including, but not limited to, use for any clinical diagnostic type use, in vitro or in vivo therapeutic use, prophylactic use, any type of consumption or application to human or animals.

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