产品详情
组分(Materials Provided)
BoxA(-20°C)IDComponentsSizeADC-P006-C0120 x Reaction buffer55ulADC-P006-C02Cofactor A55ulADC-P006-C03Cofactor B55ulADC-P006-C04Substrate A30ulADC-P006-C05Substrate B30ulADC-P006-C06Enzyme A30ulADC-P006-C07Enzyme B30ulADC-P006-C08Enzyme C25ulBoxB(4°C)IDComponentsSizeADC-P006-1-C01Binding buffer15mlADC-P006-1-C02Elution buffer1.5mlADC-P006-1-C03Neutralization buffer0.5mlADC-P006-1-C04250 mM Tris-HCl buffer (pH7.5)1.5mlADC-P006-1-C0510×PBS (pH7.2- 7.4)6mlADC-P006-1-C06Desalting column2perADC-P006-1-C07Concentrator tube2perADC-P006-1-C08ProteinA Resin100ul*2产品概述(Product Overview)
Antibody-drug conjugates (ADC) is a type of fast growing anticancer drug. Monoclonal antibody is conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. AGLink® ADC conjugation kit is designed to conjugate mAb with Tetrazine though site-specific enzymatic reaction.
应用说明(Application)
AGLink® ADC Conjugation Kit (Tetrazine, DAR2&4, 1mg) is designed to conjugate 1mg mAb with Tetrazine through site-specific enzymatic reaction.
It is for research use only.
存储(Storage)
BoxA: The unopened kit is stable for 18 months from the date of manufacture if stored under temperature ≤ -20°C. The opened kit should be stored according to components table.
BoxB: The unopened kit is stable for 18 months from the date of manufacture if stored under 4°C. The opened kit should be stored according to components table.
质量管理控制体系(QMS)
数据展示
典型数据-Typical Data
Please refer to DS document for the assay protocol.
ADC DAR value assessment by LC-TOF/MS
1.Analyst TF 1.8.1 Software was used to collect LC-TOF/MS data of samples in positive ion mode
2.PeakView was used for data processing and BioToolKit was used for deconvolution analysis.
3.DAR values are calculated using the following formula:
DAR4 =(226.11*4+114.21*3+26.32*2+14.53*1)/(226.11+114.21+26.32+14.53)=3.45ADC DAR value assessment by LC-TOF/MS
1.Analyst TF 1.8.1 Software was used to collect LC-TOF/MS data of samples in positive ion mode
2.PeakView was used for data processing and BioToolKit was used for deconvolution analysis.
3.DAR values are calculated using the following formula:
DAR2 =(1041.76*4+116.65*2)/(1041.76+116.65)=1.90
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重要声明
Statement of Rights
AGLink products are co-developed by ACROBiosystems Co., Ltd. and Glyco-therapy Biotechnology Co., Ltd. based on Glyco-therapy's conjugation platform (YTConju?) and are not authorized for commercial use. The sale and use of AGLink products doesn't represent any forms of license or authorization of the attached technologies for developing any diagnostic, therapeutic or prophylactic products for commercial purposes.
Note of application
AGLink products are intended for research use only by the Buyer or its users and can not be used for any other purposes, including, but not limited to, use for any clinical diagnostic type use, in vitro or in vivo therapeutic use, prophylactic use, any type of consumption or application to human or animals.