膜杰作
Star Staining
分子别名（Synonym）
PARK8,Leu-rich repeat/LRR-containing protein kinase 2,Dardarin
表达区间及表达系统（Source）
Human LRRK2 (G2019S), His Tag (LK2-H5245) is expressed from human 293 cells (HEK293). It contains AA Met 968 - Gln 2527 (Accession # Q5S007(G2019S)).
Predicted N-terminus: His
蛋白结构（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 179.5 kDa.
内毒素（Endotoxin）
制剂（Formulation）
Please contact us for detailed information.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 3 months under sterile conditions.
背景（Background）
Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin and PARK8, is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family, which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking. Mutations in the LRRK2 gene causes one of the most common monogenic forms of Parkinson disease (PD) . Also, several polymorphic variants in LRRK2 also modulate risk of sporadic PD.
