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 >  Protein>LINGO1 >LIO-H5256

Human LINGO1 Protein, Llama IgG2b Fc Tag

分子别名(Synonym)

LERN1, LRRN6A, MRT64, UNQ201

表达区间及表达系统(Source)

Human LINGO1 Protein, Llama IgG2b Fc Tag (LIO-H5256) is expressed from human 293 cells (HEK293). It contains AA Cys 42 - Thr 561 (Accession # Q96FE5-1).

Predicted N-terminus: Cys 42

Request for sequence

蛋白结构(Molecular Characterization)

LINGO1 Structure

This protein carries a llama IgG2b Fc tag at the C-terminus.

The protein has a calculated MW of 86.9 kDa. The protein migrates as 130-170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 0.05 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

LINGO1 SDS-PAGE

Human LINGO1 Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

 

背景(Background)

Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma.

 

前沿进展

 
 
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LINGO1靶点信息
英文全称:Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
中文全称:富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1
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上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:终止
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