膜杰作
Star Staining
& Cat.No. | Items | Size （2mg） | Size（2mg X 5） |
| Particle size | 2 μm | 2 μm |
| Physical appearance | Powder mixture | Powder mixture |
| Amount of Coupled Protein | ≈406 pmol(25.1μg) FAP protein/mg beads | ≈406 pmol(25.1μg) FAP protein/mg beads |
| Capacity | >133.3 pmol (20μg) Samrotamab /mg beads | >133.3 pmol (20μg) Samrotamab /mg beads |
| Formulation | PBS, pH7.4,with 10% Trehalose | PBS, pH7.4,with 10% Trehalose |
| Reconstitution | sterile deionized water (1 mg beads/mL) | sterile deionized water (1 mg beads/mL) |
背景（Background）
LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
应用说明（Application）
This product is intended for immunocapture, biopanning. This is a non-sterile product.
重构方法（Reconstitution）
See Certificate of Analysis (CoA) for detailed instruction.
存储（Storage）
The product is shipped at ambient temperature. Upon receipt, please store the lyophilized beads at -20℃ for long term storage. The shelf life is 1 year at -20℃ in lyophilized form.
Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.
制剂（Formulation）
Please contact us for detailed information.
Contact us for customized product form or formulation.
典型数据-Typical Data
Immobilized 25.1μg Biotinylated Human LRRC15 protein to 1mg Beads can bind the Samrotamab with an EC50 of 0.18 μg/mL (QC tested).
Protocol
