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 >  Protein>CCR5 >CC5-M52D9

Mouse CCR5 Protein, Flag,His Tag (Detergent)

分子别名(Synonym)

CCR5,CMKBR5,CD195,CC-CKR-5,CHEMR13

表达区间及表达系统(Source)

Mouse CCR5 Protein, Flag,His Tag (CC5-M52D9) is expressed from human 293 cells (HEK293). It contains AA Asp 2 - Leu 354 (Accession # P51682).

Predicted N-terminus: Asp

Request for sequence

蛋白结构(Molecular Characterization)

CCR5 Structure

This protein carries flag tag at the N-terminus and polyhistidine tag at the C-terminus.

The protein has a calculated MW of 44.1 kDa. The protein migrates as 40-43 kDa and 60-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

This product is not suitable for cell based experiments due to cytotoxicity of DDM.
DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.
DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
**The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow this link for product information.
 

电泳(SDS-PAGE)

CCR5 SDS-PAGE

Mouse CCR5 Protein, Flag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

 

背景(Background)

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.5 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.

 

前沿进展

 
 
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CCR5靶点信息
英文全称:C-C chemokine receptor type 5
中文全称:C-C趋化因子受体5型
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:13详情
最高研发阶段:批准上市
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