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 >  Protein>GPRC5D >GPD-H52D6

Human GPRC5D Full Length Protein, Flag,His Tag (Nanodisc)

分子别名(Synonym)

GPRC5D,G-protein coupled receptor family C group 5 member D

表达区间及表达系统(Source)

Human GPRC5D Full Length Protein, Flag,His Tag (GPD-H52D6) is expressed from human 293 cells (HEK293). It contains AA Tyr 2 - Cys 300 (Accession # Q9NZD1-2).

Predicted N-terminus: Asp

Request for sequence

蛋白结构(Molecular Characterization)

GPRC5D Structure

The protein has a calculated MW of 37.9 kDa.

Nanodiscs are a new class of model membranes that are being used to solubilize and study a range of integral membrane proteins and membrane-associated proteins. The Nanodisc bilayer is bounded by a membrane scaffold protein (MSP1D1) coat that confers enhanced stability and a narrow particle size distribution.

The nanodisc assembles from a mixture of full length membrane protein in detergent, phospholipid micelles and membrane scaffold protein(MSP1D1) upon removal of the detergent.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Supplied as 0.2 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
*The isotype control of empty/mock nanodisc (Cat. No. APO-H51H3) is sold separately and not included in protein, you can follow this link for product information.
 

活性(Bioactivity)-ELISA

GPRC5D ELISA

Immobilized Human GPRC5D Full Length Protein, Flag,His Tag (Cat. No. GPD-H52D6) at 1 μg/mL (100 μL/well) can bind Anti-GPRC5D Antibody, Human IgG4 with a linear range of 0.8-13 ng/mL (QC tested).

Protocol

 

背景(Background)

G-protein coupled receptor family C group 5 member D (GPRC5D) is a retinoic acid-inducible 40 kDa protein with seven transmembrane segments and a short N terminal extracellular region. Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

 

前沿进展

 
 
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GPRC5D靶点信息
英文全称:G-protein coupled receptor family C group 5member D
中文全称:G蛋白偶联受体家族C组5成员D
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:19详情
最高研发阶段:批准上市
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