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ACE2信息

英文名称:Angiotensin-converting enzyme 2
中文名称:血管紧张素转换酶 2
靶点别称:Angiotensin-converting enzyme homolog,Metalloprotease MPROT15,ACEH,Angiotensin I Converting Enzyme 2,Angiotensin-converting enzyme-related carboxypeptidase,Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2,Peptidyl-Dipeptidase A,ACE-related carboxypeptidase
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

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ACE2分子别名

ACE-2,ACEH,ACE2

ACE2分子背景

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

ACE2临床药物信息

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