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 > 【Cathepsin L】

Cathepsin L信息

英文名称：Cathepsin L
中文名称：组织蛋白酶L
靶点别称：Cathepsin L1，CATL，CTSL，MEP，EC:3.4.22.15，CTSL1，Major Excreted Protein，Cathepsin L，FLJ31037
上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期

Cathepsin L产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
CAL-H52H3
Human		 Human Cathepsin L / CTSL1 Protein, His Tag (active enzyme)
CAL-M52H3
Mouse		 Mouse Cathepsin L / CTSL1 Protein, His Tag (MALS verified)
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Cathepsin L分子别名

CTSL1,MEP,CATL,CTSL

Cathepsin L分子背景

Cathepsin L (CTSL1) is also known as major excreted protein (MEP), is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains linked by disulfide bonds. CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. MEP has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. CTSL1 is important for the overall degradation of proteins in lysosomes. The specificity of MEP is close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z - Arg – Arg – NHMec, and no peptidyl - dipeptidase activity. Human Cathepsin L activity is greatest under mildly acidic conditions, from pH 4.5 ­ 6.5. The stability of the enzyme decreases at higher pH values

Cathepsin L临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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