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GDF-2信息

英文名称:Growth/differentiation factor 2
中文名称:骨形态发生蛋白-9
靶点别称:GDF-2,BMP-9
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

GDF-2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GD2-H5211
Human
Human GDF-2 Protein, Tag Free
ACRO质量管理体系
 
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GDF-2分子别名

GDF-2,GDF2,BMP-9,BMP9

GDF-2分子背景

Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

GDF-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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