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4-1BB信息

英文名称:Tumor necrosis factor receptor superfamily member 9
中文名称:肿瘤坏死因子受体超家族成员9
靶点别称:TNFRSF9,T-cell antigen ILA,ILA,TNF Receptor Superfamily Member 9,T-Cell Antigen 4-1BB Homolog,4-1BB Ligand Receptor,CD137 Antigen,CDw137,CD137,Interleukin-Activated Receptor, Homolog Of Mouse Ly63,Tumor Necrosis Factor Receptor Superfamily, Member 9,Tumor Necrosis Factor Receptor Superfamily Member 9,Induced By Lymphocyte Activation (ILA),Homolog Of Mouse 4-1BB,Receptor Protein 4-1BB,T Cell Antigen ILA,4-1BB
上市药物数量:0
临床药物数量:71
最高研发阶段:临床三期

4-1BB产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
41B-H82E6
Human
Biotinylated Human 4-1BB / TNFRSF9 Protein, His,Avitag™(MALS verified)
41B-H53H3
Human
Human 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
41B-H5256
Human
Human 4-1BB / TNFRSF9 Protein, Mouse IgG2a Fc Tag, low endotoxin
41B-C5253
Canine
Canine 4-1BB / TNFRSF9 Protein, Fc Tag (MALS verified)
41B-C52H4
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
41B-C82E9
Cynomolgus / Rhesus macaque
Biotinylated Cynomolgus / Rhesus macaque 4-1BB / TNFRSF9 Protein, Avitag™,His Tag (MALS verified)
41B-H5253
Human
Human 4-1BB / TNFRSF9 (87-186) Protein, Fc Tag (MALS verified)
41B-H5258
Human
Human 4-1BB / TNFRSF9 Protein, Fc Tag (MALS verified)
41B-H52H9
Human
Human 4-1BB / TNFRSF9 (24-86) Protein, His Tag
41B-H52Hc
Human
Human 4-1BB / TNFRSF9 Protein, His Tag
41B-H82E4
Human
Biotinylated Human 4-1BB / TNFRSF9 (87-186) Protein, His,Avitag™ (MALS verified)
41B-H82E9
Human
Biotinylated Human 4-1BB / TNFRSF9 (24-86) Protein, His,Avitag™
41B-H82F8
Human
Biotinylated Human 4-1BB / TNFRSF9 Protein, Fc,Avitag™ (MALS verified)
41B-M5258
Mouse
Mouse 4-1BB /TNFRSF9 Protein, Fc Tag (MALS verified)
41B-M52H7
Mouse
Mouse 4-1BB / TNFRSF9 Protein, His Tag
41B-M818G0
Human
Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1 (Clone: AMH818), premium grade
41B-M82E8
Mouse
Biotinylated Mouse 4-1BB / TNFRSF9 (24-211) Protein, Avitag™,His Tag (MALS verified)
41B-R52H3
Rat
Rat 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
41B-R52H9
Rabbit
Rabbit 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
CHEK-ATF073
Human
Human 4-1BB (Luc) HEK293 Reporter Cell
CHEK-ATP038
Human
HEK293/Human 4-1BB / TNFRSF9 Stable Cell Line
ACRO质量管理体系
 
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4-1BB分子别名

TNFRSF9,4-1BB,CD137,CDw137,ILA

4-1BB分子背景

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

4-1BB临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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