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 > 【Claudin-6】

Claudin-6信息

英文名称:Claudin 6
中文名称:紧密连接蛋白6
靶点别称:UNQ757/PRO1488,Claudin-6,CLDN6,Claudin 6,Skullin
上市药物数量:0
临床药物数量:10
最高研发阶段:临床二期

抗体项目交易平台

项目名称 项目阶段 分子类型 分子来源 疾病领域 适应症
CLDN6 mAb - 01 PCC 单抗 鼠源人源化 实体瘤 卵巢癌

Claudin-6分子别名

Claudin-6,CLDN6

Claudin-6分子背景

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Claudin-6临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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