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 > 【APP】

APP信息

英文名称:Beta amyloid A4 protein
中文名称:β-淀粉状蛋白A4
靶点别称:Beta-CTF,Amyloid Beta Precursor Protein,Cerebral Vascular Amyloid Peptide,Beta-Amyloid Precursor Protein,Amyloid-Beta A4 Protein,Beta-Amyloid Peptide,Alzheimer Disease,CTFgamma,ABETA,AAA,PN2,Amyloid beta-Peptides,Amyloid intracellular domain 57,APP,Amyloid intracellular domain 59,PN-II,Alpha-secretase C-terminal fragment,AICD-50,S-APP-alpha,A4,S-APP-beta,Alzheimer disease amyloid protein,Abeta40,Gamma-CTF(59),Abeta42,Gamma-CTF(57),Alpha-CTF,Amyloid intracellular domain 50,AID(59),Gamma-CTF(50),A
上市药物数量:11
临床药物数量:39
最高研发阶段:批准上市

APP分子别名

ABPP,APPI,Amyloid-beta A4 protein

APP分子背景

Amyloid precursor protein (APP) is  a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway.  The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C103, which is subsequently cleaved by γ-secretase to release Aβ.

APP上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

APP临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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