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 > 【B7-H2】

B7-H2信息

英文名称:ICOS ligand
中文名称:ICOS配体
靶点别称:Inducible T-Cell Co-Stimulator Ligand,B7-like protein Gl50,B7-H2,B7RP-1,B7-related protein 1,B7H2,GL50,B7RP1,CD275 Antigen,ICOSL,Inducible T-Cell Costimulator Ligand,B7h,B7 Homologue 2,KIAA0653,Inducible T Cell Costimulator Ligand,Transmembrane Protein B7-H2 ICOS Ligand,ICOS-L,LICOS,B7 homolog 2,CD275,ICOSLG
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

B7-H2分子别名

ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand

B7-H2分子背景

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

B7-H2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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