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KLRG1信息

英文名称:Killer cell lectin-like receptor subfamily G member 1
中文名称:杀伤细胞凝集素样受体亚家族G成员1
靶点别称:C-type lectin domain family 15 member A,ITIM-containing receptor MAFA-L,MAFA-like receptor,Mast cell function-associated antigen,CLEC15A,MAFA,MAFAL
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

KLRG1分子别名

KLRG1

KLRG1分子背景

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

KLRG1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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