TGF-beta RI分子别名
TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5
TGF-beta RI分子背景
TGF type I receptor also called the activin receptor-like kinase 5 (ALK5) and involved in TGF signaling. TGFβ signaling is mediated by the interaction of TGFβ ligands (TGFβ 1, 2 or 3) with cell surface receptors, the TGF type I, type II and type III receptors. Signaling is initiated by binding of TGF to the TGF type II receptor forming a ligand-receptor complex which interacts with the TGF type I receptor.