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CD27 Ligand信息

英文名称:CD70 antigen
中文名称:CD70抗原
靶点别称:CD70 antigen,Surface Antigen CD70,LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand
上市药物数量:0
临床药物数量:19
最高研发阶段:临床二期

抗体项目交易平台

项目名称 项目阶段 分子类型 分子来源 疾病领域 适应症
CD70 VHH - 01 Lead 单抗 纳米抗体 实体瘤,血液瘤 肾细胞癌,非霍奇金淋巴瘤

CD27 Ligand产品列表

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CD27 Ligand分子别名

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand分子背景

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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