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 > 【SLC7A11 & SLC3A2】

SLC7A11 & SLC3A2产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
SLS-H52D3
Human & Human		 Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag (Detergent)
SLS-H52P4
Human		 Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP)
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SLC7A11 & SLC3A2分子别名

SLC7A11 & SLC3A2

SLC7A11 & SLC3A2分子背景

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.

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