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PDA-H55H3
Human		 Human PDE4A Protein, His Tag (MALS verified)
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PDE4A分子别名

phosphodiesterase 4A,cAMP-specific 3',5'-cyclic phosphodiesterase 4A

PDE4A分子背景

cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3′-5′-cyclic adenosine monophosphate (cyclic AMP) to 5′-adenosine monophosphate (AMP). PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.

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