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GFR alpha-1信息

英文名称:Glial cell line-derived neurotrophic factor receptors
中文名称:神经胶质细胞系衍生神经营养因子受体
靶点别称:Glial Cell Line-Derived Neurotrophic Factor Receptors
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

GFR alpha-1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GF1-H5224
Human
Human GFR alpha-1 Protein, His Tag
ACRO质量管理体系
 
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GFR alpha-1分子别名

GFRA1,GDNFRA,RETL1,TRNR1,GDNFR,GFR-ALPHA-1,RET1L

GFR alpha-1分子背景

GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.

GFR alpha-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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