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GITR Ligand信息

英文名称:Tumor necrosis factor ligand superfamily member 18
中文名称:肿瘤坏死因子配体超家族成员18
靶点别称:AITRL,GITRL,TL6,UNQ149,PRO175,Glucocorticoid-induced TNF-related ligand,hGITRL,Activation-inducible TNF-related ligand
上市药物数量:0
临床药物数量:0
最高研发阶段:临床前

GITR Ligand分子别名

TNFSF18,AITRL,TL6,hGITRL,GITR Ligand

GITR Ligand分子背景

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

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