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 > 【MCAM】

MCAM信息

英文名称：Melanoma cell adhesion molecule
中文名称：黑色素瘤细胞粘附分子
靶点别称：METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

MCAM产品列表

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物种
标签
属性
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货号 物种 产品描述 蛋白结构 纯度 活性
CD6-H5229
Human		 Human MCAM / CD146 Protein, His Tag
CHEK-ATP195
Human		 HEK293/Human MCAM Stable Cell Line
MCM-C52H3
Cynomolgus		 Cynomolgus MCAM / CD146 Protein, His Tag (MALS verified)
MCM-M52H3
Mouse		 Mouse MCAM / CD146 Protein, His Tag
MCM-R52H4
Rat		 Rat MCAM / CD146 Protein, His Tag
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MCAM分子别名

MCAM,CD146,MUC18

MCAM分子背景

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.
As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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