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ROR1信息

英文名称:Inactive tyrosine-protein kinase transmembrane receptor ROR1
中文名称:受体酪氨酸激酶样孤儿受体1
靶点别称:EC 2.7.10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,NTRKR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase, Receptor-Related 1,DJ537F10.1,ROR-1
上市药物数量:0
临床药物数量:12
最高研发阶段:临床三期

抗体项目交易平台

项目名称 项目阶段 分子类型 分子来源 疾病领域 适应症
ROR1 mAb - 01 Lead 单抗 全人源 实体瘤,血液瘤 B细胞淋巴瘤,乳腺癌

ROR1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
RO1-H82E6
Human / Cynomolgus / Rhesus macaque
Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
RO1-HP2E3
Human
PE-Labeled Human ROR1 Protein, His Tag (Site-specific conjugation)
RO1-HA2H4
Human
APC-Labeled Human ROR1 Protein, His TagStar Staining
CEA-B050
Human
ClinMax™ Human Soluble ROR1 ELISA Kit,PRO
CHEK-ATP084
Human
HEK293/Human ROR1 Stable Cell Line
MBR-K009
Human
Human ROR1-coupled Magnetic Beads
RO1-H5221
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag (MALS verified)
RO1-H5222
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque ROR1 (165-305, Frizzled domain) Protein, His Tag (MALS verified)
RO1-H5223
Human
Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag (MALS verified)
RO1-H522y
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag (MALS verified)
RO1-H5250
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag (MALS verified)
RO1-H5256
Human / Cynomolgus / Rhesus macaque
Human / Cynomolgus / Rhesus macaque ROR1 Protein, Mouse IgG2a Fc Tag (MALS verified)
RO1-H821y
Human / Cynomolgus / Rhesus macaque
Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Avitag™ (MALS verified)
RO1-H82F4
Human / Cynomolgus / Rhesus macaque
Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc,Avitag™ (MALS verified)
RO1-HA2H7
Human
Alexa Fluor™ 488-Labeled Human ROR1 Protein, His TagStar Staining
RO1-HF253
Human
FITC-Labeled Human ROR1 Protein, Fc Tag
RO1-HF258
Human
FITC-Labeled Human ROR1 Protein, His Tag
RO1-HP2H5
Human
PE-Labeled Human ROR1 Protein, His TagStar Staining
RO1-M5221
Mouse
Mouse ROR1 Protein, His Tag (MALS verified)
RO1-M5250
Mouse
Mouse ROR1 Protein, Fc Tag (MALS verified)
RO1-M82E3
Mouse
Biotinylated Mouse ROR1 Protein, His,Avitag™ (MALS verified)
RO1-M82F3
Mouse
Biotinylated Mouse ROR1 Protein, Fc,Avitag™ (MALS verified)
RO1-R5221
Rat
Rat ROR1 Protein, His Tag (MALS verified)
SCCHO-ATP083
Human
CHO/Human ROR1 Stable Cell Line Development Service
ACRO质量管理体系
 
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ROR1分子别名

ROR1,NTRKR1

ROR1分子背景

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

ROR1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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