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IL-23R信息

英文名称:Interleukin 23 Receptor
中文名称:白细胞介素23受体
靶点别称:IL-23 receptor,IL23R,Interleukin 23 Receptor,Interleukin-23 Receptor,IL-23R
上市药物数量:0
临床药物数量:3
最高研发阶段:申请上市

IL-23R分子别名

IL-23 R,IL-23 Receptor

IL-23R分子背景

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

IL-23R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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