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CD73信息

英文名称:5'-nucleotidase
中文名称:5'-核苷酸酶
靶点别称:5' Nucleotidase (CD73),5'-nucleotidase,5'-Nucleotidase, Ecto (CD73),Ecto-5'-nucleotidase,NT5E,5'-Nucleotidase Ecto,Ecto-5-Nucleotidase,5-NT,Purine 5-Prime-Nucleotidase,5-Nucleotidase, Ecto (CD73),5 Nucleotidase (CD73),5-Nucleotidase Ecto,5-Nucleotidase,CD73 Antigen,EC 3.1.3.5,CALJA,E5NT,ENT,NT,EN,CD73,5'-NT,NT5,NTE,EC:3.1.3.5
上市药物数量:0
临床药物数量:29
最高研发阶段:临床三期

CD73分子别名

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

CD73分子背景

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

CD73临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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