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 > 【Fc gamma RIIA / CD32a】

Fc gamma RIIA / CD32a信息

英文名称:Low affinity immunoglobulin gamma Fc region receptor II-a
中文名称:低亲和力免疫球蛋白γFc区受体II-a
靶点别称:Low affinity immunoglobulin gamma Fc region receptor II-a,FCGR2A1,Fc-gamma RII-a,CD32,FCGR2A,Fc Fragment Of IgG Receptor IIa,Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32),Immunoglobulin G Fc Receptor II,IGFR2,FCG2,Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32),Fc Gamma Receptor IIa,CD32 Antigen,CD32A,FCGR2,IgG Fc receptor II-a,CDw32,Fc-gamma-RIIa,FcRII-a,FcGR,Fc Gamma Receptor RIIa3
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

Fc gamma RIIA / CD32a产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CDA-H82E5
Human
Biotinylated Human Fc gamma RIIA / CD32a (R167) Protein, His,Avitag™ (MALS & SPR verified)
CDA-R52H5
Rat
Rat Fc gamma RIIA / CD32a Protein, His Tag (MALS & SPR verified)
CDA-R52H4
Rhesus macaque
Rhesus macaque Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & MALS verified)
CD1-H5223
Human
Human Fc gamma RIIA / CD32a (H167) Protein, His Tag (SPR & BLI & MALS verified)
CDA-C52H7
Cynomolgus
Cynomolgus Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & MALS verified)
CDA-C82E5
Cynomolgus
Biotinylated Cynomolgus Fc gamma RIIA / CD32a Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDA-H5221
Human
Human Fc gamma RIIA / CD32a (R167) Protein, His Tag (MALS & BLI verified)
CDA-H5283
Human
Human Fc gamma RIIA / CD32a (R167) Protein, Strep Tag (MALS & SPR verified)
CDA-H5284
Human
Human Fc gamma RIIA / CD32a (H167) Protein, Strep Tag (MALS & SPR verified)
CDA-H82E6
Human
Biotinylated Human Fc gamma RIIA / CD32a (H167) Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
SCCHO-ATP061H
Human
CHO/Human CD32a Stable Cell Line (High Expression) Development Service
SCCHO-ATP061L
Human
CHO/Human CD32a Stable Cell Line (Low Expression) Development Service
SCCHO-ATP061M
Human
CHO/Human CD32a Stable Cell Line (Medium Expression) Development Service
SCJUR-STF069
Human
Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
SCJUR-STF070
Human
Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
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Fc gamma RIIA / CD32a分子别名

CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2

Fc gamma RIIA / CD32a分子背景

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

Fc gamma RIIA / CD32a临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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