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 > 【Glypican 2】

Glypican 2信息

英文名称：Glypican-2
中文名称：磷脂酰肌醇蛋白2
靶点别称：Cerebroglycan，Glypican Proteoglycan 2， Cerebroglycan Proteoglycan
上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

Glypican 2产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
GP2-H52H3
Human		 Human Glypican 2 / GPC2 Protein, His Tag
GP2-M52H5
Mouse		 Mouse Glypican 2 / GPC2 Protein, His Tag
GP2-H5255
Human		 Human Glypican 2 / GPC2 Protein, Fc Tag (SPR verified)
GP2-H5253
Human		 Human Glypican 2 / GPC2 Protein, Llama IgG2b Fc Tag
GP2-R52H9
Rhesus macaque		 Rhesus macaque Glypican 2 / GPC2 Protein, His Tag
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Glypican 2分子别名

Glypican 2,GPC2

Glypican 2分子背景

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Glypican 2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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