【新品速递】【ACRO上新了】激动性靶点过表达细胞株正式开售

免疫细胞在受到外源抗原刺激时，会通过调节共刺激信号的激活以及共抑制信号的抑制，以免发生自身免疫及组织损伤。这些免疫共抑制分子以及免疫共刺激分子组成免疫检查点，精确调控免疫细胞的功能。免疫共刺激的靶点主要集中在B7-CD28家族和TNFR家族。B7-CD28家族中，CD28和ICOS为主要的共刺激受体；OX40、CD40、CD27、4‑1BB、GITR、CD30同属TNFR家族。

在过去的十几年中，T细胞免疫检查点（ICP）的发现以及CTLA-4和PD-1/PD-L1单克隆抗体抑制剂的开发彻底改变了免疫肿瘤学领域。随着竞争加剧，行业也在不断寻找新的肿瘤免疫治疗靶点，针对激动性靶点的药物研发也越来越受到人们的关注。

目前明确的参与共刺激途径的重要机制

过表达细胞株活性经FACS验证

FACS assay shows that Biotinylated Human 4-1BB, Fc,Avitag (Cat. No. 41B-H82F8) can bind to HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line (Cat. No. CHEK-ATP039). HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell was red line, Negative control HEK293 cells was grey line (QC tested).

点击申请Protocol

FACS assay shows that Monoclonal UreluMab antibody, Human IgG4 can bind to HEK293/Human 4-1BB / TNFRSF9 Stable Cell Line (Cat. No. CHEK-ATP038). HEK293/Human 4-1BB / TNFRSF9 Stable Cell Line was red line, Negative control HEK293 cells was grey line(QC tested).

点击申请Protocol

FACS assay shows that Biotinylated Human OX40 Ligand, Avitag,Fc Tag (Cat. No. OXL-H82F4) can bind to HEK293/Human OX40 / TNFRSF4 / CD134 Stable Cell Line(Cat. No. CHEK-ATP053). HEK293/Human OX40 / TNFRSF4 / CD134 Stable Cell Line was red line, Negative control HEK293 cells was grey line(QC tested).

点击申请Protocol

FACS assay shows that Biotinylated Human OX40, Avitag,His Tag (Cat. No. TN4-H82E4) can bind to HEK293/Human OX40 Ligand / TNFSF4 Stable Cell Line (Cat. No. CHEK-ATP054). HEK293/Human OX40 Ligand / TNFSF4 Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).

点击申请Protocol

除过表达细胞株以外，ACROBiosystems百普赛斯作为药物开发用重组蛋白的行业领导者，秉承“从靶点蛋白开始，为更好生物医药”的理念，开发优化了一系列高纯度、天然聚体结构经MALS验证、高生物活性经ELISA/SPR/BLI/Cell based assay等验证的激动性靶点产品，适用于免疫、抗体筛选、细胞活性检测等实验，可加速抗体药物等的开发进程。

参考文献

1. Pourakbari R, Hajizadeh F, Parhizkar F, Aghebati-Maleki A, Mansouri S, Aghebati-Maleki L. Co-stimulatory agonists: An insight into the immunotherapy of cancer. EXCLI J. 2021 Jun 9;20:1055-1085. doi: 10.17179/excli2021-3522. PMID: 34267616; PMCID: PMC8278219.