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ActiveMax® Human BCMA μBeads, premium grade (for cells) DMF

热销产品推荐:The Magnetic Stand (Cat.No. MB-01 & Cat.No. MB-02) can be used in conjunction with Beads.
ClinMaxTM细胞因子检测试剂盒

ProductSizeAmount
ActiveMax® Human BCMA μBeads, premium grade (for cells)2.5 mg2.5 × 10⁷ beads
ActiveMax® Human BCMA μBeads, premium grade (for cells)10 mg (2.5 mg × 4)1.0 × 10⁸ beads

背景(Background)

ActiveMax® Human BCMA μBeads, premium grade (for cells) are produced under sterile manufacturing conditions (ISO 5), and no animal- or human-derived components are used throughout the production process. It is produced under our rigorous quality control system that includes a comprehensive set of tests including sterility and endotoxin tests.

表达区间及表达系统(Source)

ActiveMax® Human BCMA μBeads, premium grade (for cells) are uniform, superparamagnetic beads of 5.5 µm with streptavidin on its surface and coupled with biotinylated Human BCMA Protein, expressed from human 293 cells (HEK293) and contains AA Met 1 - Ala 54 (Accession # Q02223-1).

应用说明(Application)

ActiveMax® Human BCMA μBeads, premium grade (for cells) are designed to stimulate in vitro BCMA-specific CAR-T cells or UCAR-T cells, similar to the tumor cell lines that express human BCMA antigen. It can be used as follows:
Evaluating the characteristics of CAR-T cells or UCAR-T cells.
In vitro expansion of BCMA-specific CAR-T cells or UCAR-T cells.
In vitro enrichment of BCMA-specific CAR-T cells or UCAR-T cells.

*We also carry ActiveMax® Streptavidin μBeads, premium grade (for cells)(Cat. No. MBS-C009),and it can be used for convenient preparation of your own sterile protein/antibody coupled beads for cell based assay, cell sorting and other applications.

重构方法(Reconstitution)

See Certificate of Analysis (CoA) for detailed instruction.

存储(Storage)

This product is stable in storage under the following conditions: -20˚C for 12 months in lyophilized state. -70°C for 3 months under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles after reconstitution. Immediate use after reconstitution is highly recommended.

无菌(Sterility)

Negative

内毒素(Endotoxin)

Less than 0.002 EU per μg by the LAL method.

注意事项(Important Note)

This product is for research use only and not intended for therapeutic or in vivo diagnostic use.

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

质量管理控制体系(QMS)

  1. 质量管理体系(ISO, GMP)
  2. 质量优势
  3. 质控流程
 

典型数据-Typical Data Please refer to DS document for the assay protocol.

BCMA TYPICAL DATA

Assay of human BCMA protein on the μBeads surface by Flow cytomtry. The human BCMA conjugated on the μBeads (Cat. No. MBS-C004) surface were fluorescently stained using PE labeled anti-human BCMA antibody and analyzed by flow cytometry.

 
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前沿进展

Penile metastasis from colon cancer with BRAF V600E mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report
Wu, Cheng, Lan et al
World J Gastrointest Oncol (2025) 17 (3), 100152
Abstract: The incidence of colon cancer has been progressively increasing over time, whereas penile metastasis of colon cancer has remained exceedingly uncommon. Since the prognosis for colon cancer with BRAF V600E mutation is relatively unfavorable, further exploration and investigation are still required to develop treatment strategies for such rare cases.About one year after surgery and chemotherapy, a 50-year-old patient with sigmoid colon cancer developed a mass at the base of the patient's penis, accompanied by severe tenderness and pain during urination. With disease progression, multiple metastatic nodules also emerged in other regions of the penis, including the coronal sulcus. The nodules located in the coronal sulcus were excised for histopathological examination. The histopathological findings revealed that the nodules were metastases originating from the sigmoid colon cancer, with a BRAF V600E mutation detected. This prompted a modification of the therapy regimen of cetuximab, dabrafenib and trametinib, which effectively held back the progression of penile metastasis in the patient.Combining the BRAF/MEK-targeted therapy with cetuximab demonstrates a favorable therapeutic response in BRAF V600E-mutated colon cancer with penile metastasis.©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
HER2-targeted therapy in colorectal cancer: a comprehensive review
Benli, Arıkan, Akbulut-Çalışkan
Clin Transl Oncol (2025)
Abstract: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Despite treatment advancements in the last decades, CRC remains heterogeneous with significant clinical and genetic diversity. Human epidermal growth factor receptor 2 (HER2) proto-oncogene plays a critical role, as its amplification or overexpression leading to abnormal cell proliferation and tumorigenesis. HER2 overexpression or amplification is identified in 2-4% of metastatic CRCs (mCRC) patients, representing a potential therapeutic target. It is also associated with resistance against epidermal growth factor receptor (EGFR)-targeted therapies like cetuximab and panitumumab, for treatment of RAS wild-type mCRC. Although HER2-positive mCRC is rare, assessing HER2 levels is important. Furthermore, anti-HER2 therapies exhibited non-toxic profile and high efficacy in chemorefractory cases. This review delves into modern management of anti-HER2 therapies in CRC with a particular focus on recent advances and current knowledge about the prognostic and predictive value of HER2.© 2025. The Author(s).
The emerging role of Sotorasib plus Panitumumab combination therapy in colorectal cancer treatment
Kokori, Olatunji, Ogieuhi et al
Int J Clin Oncol (2025)
Abstract: Colorectal cancer (CRC) poses a substantial global health challenge, ranking as the third most commonly diagnosed and second most fatal cancer worldwide. With an increasing incidence, particularly in older populations, CRC demands innovative therapeutic approaches to address the limitations of existing treatments. One critical target in CRC is the KRAS gene, which is frequently mutated and implicated in various cancer-related processes. This narrative review explores the promising role of Sotorasib plus Panitumumab combination therapy in CRC treatment. Combining Sotorasib with Panitumumab, an EGFR antagonist, offers a synergistic approach to comprehensively block KRAS and EGFR pathways, potentially overcoming resistance mechanisms observed in monotherapies. The review discusses the evolution of CRC treatment from traditional chemotherapy to the advent of targeted therapies like Bevacizumab and Cetuximab. It highlights the limitations of existing therapies, including resistance and toxicities, emphasising the urgency for innovative approaches. The CodeBreak clinical trials, specifically CodeBreak 101 and CodeBreak 300, provide a focal point for evaluating the efficacy of Sotorasib plus Panitumumab in patients with refractory KRAS G12C-mutated mCRC. Preliminary results demonstrate significant improvements in progression-free survival (PFS) and objective response rates, suggesting a paradigm shift in CRC treatment. The preliminary findings from the CodeBreak 300 trial signify a transformative impact of Sotorasib plus Panitumumab in refractory KRAS G12C-mutated mCRC. With a notable increase in PFS and objective response rates and a well-tolerated safety profile, this combination therapy emerges as a potential new standard of care. The results present an optimistic outlook for patients resistant to conventional therapies.© 2025. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.
Dual Potential of Cetuximab Conjugated Hydroxyapatite Zirconium Nanoparticle as Nanocarrier for Radioenhancer in X-Ray Dynamic Therapy and 177Lu-based Radioimmunotherapy of Lung Cancer
Kurniawan, Mahendra, Rizaludin et al
Nanotheranostics (2025) 9 (1), 82-94
Abstract: This study aimed to synthesize cetuximab (CTX) conjugated hydroxyapatite zirconium (HApZr-CTX) as a nanocarrier for active delivery of photosensitizer and therapeutic radionuclide. The system enabled targeted radioenhancer in X-ray dynamic therapy and radioimmunotherapy for lung cancer. The results showed that HApZr-CTX had the main characteristics of hydroxyapatite crystal in X-ray powder diffraction (XRD), with particle size twice bigger, according to DLS-PSA and TEM measurements. Cellular ROS generation was elevated almost three times in A549 cells after being treated using 125 µg/mL HApZr-CTX and irradiated with 5 Gy of X-ray photon compared to untreated cells. The viability of the treated lung cancer cell line decreased after exposure to external radiation. Moreover, as a radioimmunotherapy candidate, 177Lu was successfully loaded into HApZr-CTX nanocarrier and internalized in A549 more than half of the given dose after 0.5 h incubation. [177Lu]Lu-HApZr-CTX was primarily accumulated in the lung organs of healthy mice one-hour post-injection. In conclusion, HApZr-CTX nanoparticles have the potential to be used as a radioenhancer in X-ray dynamic therapy and radioimmunotherapy for lung cancer therapy.© The author(s).
Showing 1-4 of 9352 papers.
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BCMA靶点信息
英文全称:B-cell maturation protein
中文全称:B细胞成熟蛋白
种类:Homo sapiens
上市药物数量:7详情
临床药物数量:117详情
最高研发阶段:临床三期
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