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CD19信息

英文名称:B-lymphocyte antigen CD19
中文名称:B淋巴细胞抗原CD19
靶点别称:Differentiation antigen CD19,CD19 Molecule,B-Lymphocyte Surface Antigen B4,CD19 Antigen,B-Lymphocyte Antigen CD19,CVID3,B4,Antigens, CD19,CD19,T-cell surface antigen Leu-12
上市药物数量:11
临床药物数量:291
最高研发阶段:批准上市

抗体项目交易平台

项目名称 项目阶段 分子类型 分子来源 疾病领域 适应症
CD19 mAb - 01 PCC 单抗 鼠源人源化 自免,血液瘤 非霍奇金淋巴瘤

Licensing 项目合作

项目名称 药物类型 治疗领域 适应症 阶段 权益地区
CD3 + CD19双特异性抗体 双抗,多抗 自免性疾病 自身免疫疾病 IND 全球
CD19 全人源单抗 单抗 免疫类疾病 自身免疫性疾病、B细胞恶性肿瘤 IND 全球

CD19产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD9-HP2H3
Human
PE-Labeled Human CD19 (20-291) Protein, His Tag (Site-specific conjugation)
CD9-H82E9
Human
Biotinylated Human CD19 (20-291) Protein, His,Avitag™, premium grade
CD9-HF2H2
Human
FITC-Labeled Human CD19 (20-291) Protein, His Tag
CD9-C5221
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque CD19 (20-292) Protein, His Tag
CD9-C5251
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag
CD9-C52H4
Canine
Canine CD19 Protein, His Tag
CD9-C5354
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag (MALS & SPR verified)
CD9-H5251
Human
Human CD19 (20-291) Protein, Fc Tag, premium grade
CD9-H5258
Human
Human CD19 (20-291) Protein, Mouse IgG2a Fc Tag (MALS verified)
CD9-H5259
Human
Human CD19 (20-291) Protein, Fc Tag, low endotoxin
CD9-H52H2
Human
Human CD19 (20-291) Protein, His Tag
CD9-H8259
Human
Biotinylated Human CD19 Protein, Fc Tag, ultra sensitivity (primary amine labeling)
CD9-H82F6
Human
Biotinylated Human CD19 (20-291) Protein, Fc,Avitag™, premium grade
CD9-HA2H3
Human
Alexa Fluor™ 488-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H5
Human
APC-Labeled Human CD19 (20-291) Protein, His Tag (Site-specific conjugation)
CD9-HA2H6
Human
Alexa Fluor™ 647-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H7
Human
Alexa Fluor™ 555-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H9
Human
APC-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HF251
Human
FITC-Labeled Human CD19 (20-291) Protein, Fc Tag
CD9-HF2H3
Human
FITC-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HP2H5
Human
PE-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-M52H8
Mouse
Mouse CD19 Protein, His Tag
CD9-R52H3
Rabbit
Rabbit CD19 Protein, His Tag
CD9-R52H6
Rat
Rat CD19 Protein, His Tag
CHEK-ATP003
Human
HEK293/Human CD19 Stable Cell Line
CHEK-ATS056
Human
HEK293/Human Anti-CD19 Stable Cell Line
FABm004-02
Mouse
APC-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63)
MBS-C002
Human
ActiveMax® Human CD19 μBeads, premium grade (for cells)
MBS-K005
Human
Human CD19-coupled Magnetic Beads
ACRO质量管理体系
 
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CD19分子别名

CD19,B4,CVID3,MGC12802

CD19分子背景

B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I  membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.

CD19上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

CD19临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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