功能细胞系 - ACROBiosystems百普赛斯生物科技股份有限公司

背景

自1986年全球首个鼠源单克隆抗体药物莫罗莫那单抗（muromonab-CD3）经美国FDA批准上市至今，抗体药物历经数十年的研究与发展，已经成为生物药中增长最快的领域并彻底改变了癌症等一系列疾病的治疗格局。目前，全球范围内已有近百个抗体类药物获批上市，在临床治疗、体外诊断、科学研究等领域发挥重要作用。

细胞水平的分析评价是体外进行药物有效性评估的重要指标之一，被广泛地应用在新药研发过程中。但是由于所选用细胞的局限性，很多传统的细胞水平活性分析方法有着灵敏度低，重复性差，操作复杂，检测周期长，通量低等缺点,。比如选用原代细胞的分析方法，由于原代细胞的批间差异大，导致分析方法非常不稳定，因此无法满足新药研发的需求。

通过基因工程方法构建的报告基因细胞株（Reporter cell line）被认为可以克服传统细胞水平分析方法缺点而被逐步广泛运用到新药研发的进程中。报告基因细胞株（Reporter cell line）以药物作用机制（MOA）为基础，在细胞内建立起靶点转导信号与报告基因表达的相关性，通过检测报告基因的表达情况以监控靶点信号通路转导，进而构建一种药物靶点特异性的模型细胞株。这类细胞株批间差小，且转入细胞内的检测信号强，以此为基础开发的分析方法灵敏度高，检测周期短，重复性好，并且操作简单。

为满足新药物研发的需求，ACROBiosystems采用荧光素酶报告基因系统建立报告基因细胞平台，持续开发系列高质量报告基因细胞株产品。ACRO开发的系列细胞株产品均通过功能性和稳定性验证，可以应用于信号传导功能研究、早期药物发现与筛选及CMC质控放行，为新药研发提供一个稳定且便捷的工具！

超高品质+兜底售后，给您不可不选择ACRO报告基因细胞株的五大理由！

应用场景

ADCC/ADCP功能验证

靶点及通路研究

Cross-linking药物评价

免疫检查点抗体研究

如需定制其他报告基因细胞系或过表达细胞系，欢迎点击此处了解详细信息

产品优势：

基于明确MOA设计，便于药物机制研究；

应用场景明确，方便客户选择；

配套产品供应，实现一站服务；

反应信号强，确保高灵敏度；

检测窗口大，适用不同药效筛选；

可稳定传代>20代，利于方法学验证；

可提供临床申报及CMC所需支持文件；

产品列表

ADCC/ADCP功能验证
靶点及通路研究
Cross-linking药物评价
免疫检查点药物研究

应用	Molecule	Cat. No.	Product description
ADCP	FcγRI(CD64A)	SCJUR-STF072	Human CD64 (Luc) Jurkat Reporter Cell Development Service
	FcγRIIa(CD32a)-H131	SCJUR-STF069	Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
	FcγRIIa(CD32a)-R131	SCJUR-STF070	Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
	FcRIIb (CD32b)	SCJUR-STF071	Human CD32b (Luc) Jurkat Reporter Cell Development Service
ADCC	FcRIIIa (CD16a)-V158	SCJUR-STF067	Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
ADCC	FcRIIIa (CD16a)-F158	SCJUR-STF068	Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service

分子	货号	Reporter Cell Product Description
5-HT1A	CHEK-ATF131	Human 5-HT1A (Luc) HEK293 Reporter Cell
Activin RII	CHEK-ATF164	Human Activin RII (Luc) HEK293 Reporter Cell
BMP	CHEK-ATF188	Human BMP (Luc) HEK293 Reporter Cell
DR3	SCJUR-STF178	Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell Development Service
EGF R	CHEK-ATF049	EGFR (Luc) HEK293 Reporter Cell
FGF-21	CHEK-ATF163	Human FGF-21 (Luc) HEK293 Reporter Cell
GCGR	CHEK-ATF103	Human GCGR (Luc) HEK293 Reporter Cell
GIPR	CHEK-ATF104	Human GIPR (Luc) HEK293 Reporter Cell
GLP1R	CHEK-ATF096	Human GLP-1R (Luc) HEK293 Reporter Cell
GLP2R	CHEK-ATF128	Human GLP-2R (Luc) HEK293 Reporter Cell
HGF R	CHEK-ATF144	Human c-MET (Luc) HEK293 Reporter Cell
IGF-I R	CHEK-ATF107	Human IGF-1 R (Luc) HEK293 Reporter Cell
IL-10 R alpha/IL-10 R beta	CHEK-ATF095	Human IL-10 R alpha/IL-10 R beta (Luc) HEK293 Reporter Cell
IL-11 R alpha	CHEK-ATF052	Human IL-11 R alpha (Luc) HEK293 Reporter Cell
IL-17 RA & IL-17 RC	CHEK-ATF133	Human IL-17 RA/IL-17 RC (Luc) HEK293 Reporter Cell
IL-2 R beta & IL-2 R gamma	CHEK-ATF136	Human IL-2 R beta/IL-2 R gamma (Luc) HEK293 Reporter Cell
IL-21 R	CHEK-ATF051	Human IL-21 R/CD132 (Luc) HEK293 Reporter Cell
IL-22 R alpha 1/IL-10 R beta	CHEK-ATF167	Human IL-22 R alpha 1/IL-10 R beta (Luc) HEK293 Reporter Cell
IL-23 R/IL-12 R beta 1	CHEK-ATF166	Human IL-23 R/IL-12 R beta 1(Luc) HEK293 Reporter Cell
IL-31 RA / OSMR	CHEK-ATF094	Human IL-31 RA/OSMR (Luc) HEK293 Reporter Cell
IL-4 R alpha/IL-13 R alpha 1	CHEK-ATF075	Human IL-4 R alpha/IL-13 R alpha 1 (Luc) HEK293 Reporter Cell
IL-5 R alpha/CD131	CHEK-ATF074	Human IL-5 R alpha/CD131 (Luc) HEK293 Reporter Cell
IL-7 R alpha & IL-2 R gamma	CHEK-ATF099	Human IL-7 R alpha/CD132 (Luc) HEK293 Reporter Cell
IL-7 R alpha & TSLP R	CHEK-ATF045	Human TSLP R (Luc) HEK293 Reporter Cell
ISRE	CHEK-ATF134	ISRE (Luc) HEK293 Reporter Cell
NF-κB	CHEK-ATF048	NF-κB (Luc) HEK293 Reporter Cell
NF-κB	SCJUR-STF113	NF-kB (Luc) Jurkat Reporter Cell Development Service
NFAT	CHEK-ATF050	NFAT (Luc) HEK293 Reporter Cell
NFAT	SCJUR-STF046	NFAT (Luc) Jurkat Reporter Cell Development Service
NKp46	SCJUR-STF130	Human NKp46 (Luc) Jurkat Reporter Cell Development Service
OX40	CHEK-ATF135	Human OX40 (Luc) HEK293 Reporter Cell
RANK	CHEK-ATF129	Human RANK (Luc) HEK293 Reporter Cell
STAT3	CHEK-ATF047	STAT3 (Luc) HEK293 Reporter Cell
TCF/LEF	CHEK-ATF114	TCF/LEF (Luc) HEK293 Reporter Cell
TGF-beta 1	CHEK-ATF145	Human TGF-beta R (Luc) HEK293 Reporter Cell
THRA	CHEK-ATF180	Human THRA (Luc) HEK293 Reporter Cell
THRB	CHEK-ATF181	Human THRB (Luc) HEK293 Reporter Cell
TrkA	CHEK-ATF093	Human TrkA (Luc) HEK293 Reporter Cell
TSHR	CHEK-ATF187	Human TSHR (Luc) HEK293 Reporter Cell
VEGF R2	CHEK-ATF044	Human VEGF R2 (Luc) HEK293 Reporter Cell
分子	货号	Stable Cell Product Description
4-1BB	CHEK-ATP038	HEK293/Human 4-1BB / TNFRSF9 Stable Cell Line
4-1BB Ligand	CHEK-ATP039	HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line
Alpha-Synuclein	CHEK-ATP085	HEK293/Human Alpha-synuclein (GFP) Stable Cell Line
APP	CHEK-ATP081	HEK293/Human APP (GFP) Stable Cell Line
ASGR1	CHEK-ATP080	HEK293/Human ASGR1 Stable Cell Line
ASGR1&ASGR2	CHEK-ATP172	HEK293/Human ASGR1&ASGR2 Stable Cell Line
B7-H3 (4Ig)	SCCHO-ATP169	CHO/Human B7-H3 (4Ig) Stable Cell Line Development Service
B7-H4	CHEK-ATP126	HEK293/Human B7-H4 Stable Cell Line
Cadherin-17	CHEK-ATP173	HEK293/Human Cadherin-17 Stable Cell Line
Cadherin-6	CHEK-ATP127	HEK293/Human Cadherin-6 Stable Cell Line
CCR5	CHEK-ATP043	HEK293/Human CCR5 Stable Cell Line
CCR8	CHEK-ATP140	HEK293/Human CCR8 Stable Cell Line
CD19	CHEK-ATS056	HEK293/Human Anti-CD19 Stable Cell Line
CD20	CHEK-ATP034	HEK293/Human CD20 Stable Cell Line
CD79A & CD79B	SCCHO-ATP170	CHO/Human CD79A&CD79B Stable Cell Line Development Service
CD79B	SCCHO-ATP171	CHO/Human CD79B Stable Cell Line Development Service
CEACAM-5	CHEK-ATP083	HEK293/Human CEACAM5 Stable Cell Line
CEACAM-5	SCCHO-ATP081	CHO/Human CEACAM5 Stable Cell Line Development Service
Claudin-1	CHEK-ATP124	HEK293/Human Claudin-1 Stable Cell Line
Claudin-18.2	CHEK-ATP033	HEK293/Human Claudin-18.2 Stable Cell Line
Claudin-6	CHEK-ATP138	HEK293/Human Claudin-6 Stable Cell Line
Claudin-9	CHEK-ATP139	HEK293/Human Claudin-9 Stable Cell Line
DLL3	CHEK-ATP090	HEK293/Human DLL3 Stable Cell Line
DLL3	SCCHO-ATP111	CHO/Human DLL3 Stable Cell Line Development Service
EGF R	CHEK-ATP148	HEK293/Human EGF R Stable Cell Line
ENPP3	CHEK-ATP122	HEK293/Human ENPP3 Stable Cell Line
EpCAM	CHEK-ATP175	HEK293/Human EpCAM Stable Cell Line
ErbB3	CHEK-ATP149	HEK293/Human ErbB3 Stable Cell Line
FAP	CHEK-ATP184	HEK293/Human FAP Stable Cell Line
FcRn (FCGRT & B2M)	CHEK-ATP079	HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line
FcRn (FCGRT & B2M)	CHEK-ATP132	HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line
FOLR1	CHEK-ATP091	HEK293/Human FOLR1 Stable Cell Line
GLP1R	CHEK-ATP160	HEK293/Human GLP-1R Stable Cell Line (High Expression)
GLP1R	CHEK-ATP161	HEK293/Human GLP-1R Stable Cell Line (Medium Expression)
GLP1R	CHEK-ATP162	HEK293/Human GLP-1R Stable Cell Line (Low Expression)
Glypican 3	CHEK-ATP092	HEK293/Human Glypican-3 (GPC3) Stable Cell Line
Glypican 3	CHEK-ATP177	HEK293/Cynomolgus Glypican-3 (GPC3) Stable Cell Line
Glypican 3	SCCHO-ATP112	CHO/Human Glypican-3 (GPC3) Stable Cell Line Development Service
Glypican-3	SCCHO-ATP179	CHO/Cynomolgus Glypican-3 (GPC3) Stable Cell Line Development Service
GPR75	CHEK-ATP174	HEK293/Human GPR75 Stable Cell Line
GPRC5D	CCHO-STP078	CHO/Human GPRC5D Stable Cell Line
GPRC5D	CHEK-STP042	HEK293/Human GPRC5D Stable Cell Line
GUCY2C	CHEK-ATP182	HEK293/Human GUCY2C Stable Cell Line
Her2	CHEK-ATP150	HEK293/Human ErbB2 Stable Cell Line
HGF R	CHEK-ATP146	HEK293/Human c-MET Stable Cell Line
HGF R	SCCHO-ATP141	CHO/Human c-MET Stable Cell Line Development Service
HVEM	CHEK-ATP147	HEK293/Human HVEM Stable Cell Line
IGF-I R	CNIH-ATP102	NIH-3T3/Human IGF-1 R Stable Cell Line Development Service
Integrin alpha V beta 6	CHEK-ATP125	HEK293/Human Integrin alpha V beta 6 Stable Cell Line
LDL R	CHEK-ATP158	HEK293/Human LDL R Stable Cell Line
LILRB3	CHEK-ATP159	HEK293/Human LILRB3 Stable Cell Line
LILRB4	CHEK-ATP088	HEK293/Human LILRB4 Stable Cell Line
LILRB4	SCCHO-ATP087	CHO/Human LILRB4 Stable Cell Line Development Service
LRRC15	CHEK-ATP123	HEK293/Human LRRC15 Stable Cell Line
LY6G6D	CHEK-ATP137	HEK293/Human LY6G6D Stable Cell Line
Mesothelin	CHEK-ATP119	HEK293/Human Mesothelin Stable Cell Line
Mesothelin	SCCHO-ATP120	CHO/Human Mesothelin Stable Cell Line Development Service
NAPI-IIb	CHEK-ATP116	HEK293/Human NAPI-IIb Stable Cell Line
Nectin-4	CHEK-ATP035	HEK293/Human Nectin-4 Stable Cell Line
NGFR	CHEK-ATP157	HEK293/Human NGFR Stable Cell Line
NKp46	CHEK-ATP153	HEK293/Human NKp46 Stable Cell Line
NY-ESO-1	CHEK-STP114	NY-ESO-1 specific TCR-HEK293 cell line
OX40	CHEK-ATP053	HEK293/Human OX40 / TNFRSF4 / CD134 Stable Cell Line
OX40 Ligand	CHEK-ATP054	HEK293/Human OX40 Ligand / TNFSF4 Stable Cell Line
PD-L1	CHEK-ATP002	HEK293/Human PD-L1, GFP Tag Stable Cell Line
PSMA	CHEK-ATP185	HEK293/Human PSMA Stable Cell Line
PTK7	CHEK-ATP186	HEK293/Human PTK7 Stable Cell Line
RAGE	CHEK-ATP156	HEK293/Human RAGE Stable Cell Line
ROR1	CHEK-ATP084	HEK293/Human ROR1 Stable Cell Line
ROR1	SCCHO-ATP083	CHO/Human ROR1 Stable Cell Line Development Service
SEZ6	CHEK-ATP183	HEK293/Human SEZ6 Stable Cell Line
SIRP alpha	CHEK-ATP051	HEK293/Human SIRP alpha Stable Cell Line
Sortilin	CHEK-ATP155	HEK293/Human SORT1 Stable Cell Line
STEAP1	CHEK-ATP154	HEK293/Human STEAP1 Stable Cell Line
STEAP1	SCCHO-ATP121	CHO/Human STEAP1 Stable Cell Line Development Service
Tau	CHEK-ATP087	HEK293/Human Tau-K18 (GFP) Stable Cell Line
TL1A	CHEK-ATP142	HEK293/Human TL1A Stable Cell Line
TMPRSS2	CHEK-ATP101	HEK293/Human TMPRSS2-HA-P2A-mGFP Stable Cell Line
TPBG	CHEK-ATP176	HEK293/Human TPBG Stable Cell Line
Transferrin	CHEK-ATP115	HEK293/Human Transferrin Stable Cell Line
Transferrin R	CHEK-ATP089	HEK293/Human Transferrin R Stable Cell Line
TrkA	CHEK-ATP192	HEK293/Human TrkA Stable Cell Line
TrkB	CHEK-ATP082	HEK293/Human TrkB Stable Cell Line
TrkC	CHEK-ATP189	HEK293/Human TrkC Stable Cell Line
TROP-2	CHEK-ATP036	HEK293/Human TROP-2 Stable Cell Line
TSHR	CHEK-ATP086	HEK293/Human TSHR Stable Cell Line
TSHR	SCCHO-ATP085	CHO/Human TSHR Stable Cell Line Development Service
uPAR	CHEK-ATP151	HEK293/Human uPAR Stable Cell Line
uPAR	SCCHO-ATP152	CHO/Human uPAR Stable Cell Line Development Service

Molecule	Cat. No.	Product Description
4-1BB	CHEK-ATF073	Human 4-1BB (Luc) HEK293 Reporter Cell
CD40	CHEK-ATF097	Human CD40 (Luc) HEK293 Reporter Cell
Fc gamma RI / CD64	SCCHO-ATP062H	CHO/Human CD64 Stable Cell Line (High Expression) Development Service
Fc gamma RI / CD64	SCCHO-ATP062L	CHO/Human CD64 Stable Cell Line (Low Expression) Development Service
Fc gamma RI / CD64	SCCHO-ATP062M	CHO/Human CD64 Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061H	CHO/Human CD32a Stable Cell Line (High Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061L	CHO/Human CD32a Stable Cell Line (Low Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061M	CHO/Human CD32a Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060H	CHO/Human CD32b Stable Cell Line (High Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060L	CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060M	CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIIA / CD16a	SCCHO-ATP059H	CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
Fc gamma RIIIA / CD16a	SCCHO-ATP059L	CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
Fc gamma RIIIA / CD16a	SCCHO-ATP059M	CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
PD-L1	SCCHO-ATP077H	CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
PD-L1	SCCHO-ATP077L	CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
PD-L1	SCCHO-ATP077M	CHO/Human PD-L1 Stable Cell Line (Medium Expression) Development Service

Molecule	Cat. No.	Product Description
BTLA	SCCHO-ATP110	CHO/Human BTLA Stable Cell Line Development Service
BTLA	SCJUR-STF106	Human BTLA (Luc) Jurkat Reporter Cell Development Service
CD155	SCRAJ-STT076	Raji/Human CD155 Stable Cell Line Development Service
Fc gamma RIIIA / CD16a	SCJUR-STF067	Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
HVEM	CHEK-ATF105	Human HVEM (Luc) HEK293 Reporter Cell
HVEM	SCRAJ-STF108	Raji/Human HVEM Stable Cell Line Development Service
LAG-3	SCJUR-STF065	Human LAG-3 (Luc) Jurkat Reporter Cell Development Service
LIGHT	SCCHO-ATP109	CHO/Human LIGHT Stable Cell Line Development Service
PD-1	CHEK-ATP143	HEK293/Human PD-1 Stable Cell Line
PD-1	SCJUR-STF064	Human PD-1 (Luc) Jurkat Reporter Cell Development Service
PD-1/LAG-3	SCJUR-STF063	Human PD-1/LAG-3 (Luc) Jurkat Reporter cell Development Service
PD-L1	SCRAJ-STT075	Raji/Human PD-L1 Stable Cell Line Development Service
TIGIT	SCJUR-STF066	Human TIGIT (Luc) Jurkat Reporter Cell Development Service

在线留言

发送

免疫检查点蛋白

自免疾病靶点

细胞因子靶点

GMP级别产品

细胞疗法靶点

Enzymes

全长多次跨膜蛋白

脑与神经蛋白

肿瘤微环境蛋白

信号通路蛋白

其它蛋白

免疫组化 (IHC) 抗体

抗独特型抗体

同型对照

通用型抗体

其他抗体

抗体服务

GMP级别生长因子

细胞激活

细胞培养添加剂

细胞培养基

其他产品

ELISA

qPCR试剂盒

流式细胞术

ADC 偶联试剂盒

免疫组化（IHC）试剂盒

MPCLIA

其它试剂盒

新冠病毒

水痘-带状疱疹病毒

流感病毒

疱疹病毒

呼吸道合胞病毒

狂犬病毒

其他传染病相关试剂

ViruStop检测服务

iPSC分化的即用型活体类器官

类器官分化试剂盒

类器官维持试剂盒

类器官冷冻保存试剂盒

类器官培养试剂

类器官技术服务

类器官病理检测服务

实验试剂

功能细胞株 (Cellinsight)

神经科学在体电生理实验解决方案

实验仪器设备

CAR靶点蛋白

通用型CAR检测工具

通用型蛋白

其它靶点蛋白

药物筛选与分析服务

伴随诊断

细胞培养产品

Premium(Pre-GMP) & GMP 级别原材料

基因编辑产品

大规模生产

核酸去除产品

CAR检测工具

效力测定

残留检测试剂盒 - resDetect

药代动力学研究

免疫原性研究

药效学研究

审计&申报文件支持

毒理研究

伴随诊断

药代动力学研究

免疫原性研究

毒理研究

基因编辑

AAV颗粒滴度定量检测试剂盒

伴随诊断

Premium(Pre-GMP) & GMP 级别原材料

核酸去除

基因编辑

AAV颗粒滴度定量检测试剂盒

大规模生产

残留检测 - resDetect